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Posts tagged "MCAS"

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histamine MCAS inflammation

Histamine Intolerance and the Vagus: When the Bucket Overflows

Histamine intolerance is not an allergy. It is a mismatch between histamine load and the body's capacity to clear it — and autonomic state sits on both sides of that equation.

By UltraSkool Research Team Jul 4, 2026

EDS hypermobility POTS

The EDS–POTS–MCAS Trifecta: Why Hypermobile Patients Need a Different Plan

Hypermobility, dysautonomia, and mast cell activation are not three coincidences. They cluster for biological reasons — and once you see the pattern, the treatment sequence becomes obvious.

By UltraSkool Research Team May 10, 2026

MCAS mast cell histamine

MCAS, the Vagus Nerve, and the Cholinergic Anti-Inflammatory Reflex

Mast cell activation is not just an allergy problem. It is a failure of the vagal brake on innate immunity — and the cholinergic anti-inflammatory pathway is one of the most promising therapeutic levers.

By UltraSkool Research Team May 10, 2026